반응 #794529

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N1-(3-nitropyridin-2-yl)cyclohexane-1,4-diamine

2-chloro-1H-benzoimidazole

→

N1-(1H-benzo[d]imidazol-2-yl)-N4-(3-nitropyridin-2-yl)cyclohexane-1,4-diamine

수율 53.8%

용매

water

N-methylpyrrolidinone

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (2×50 mL)
2. 2
   건조The organic layer was dried over sodium sulfate
3. 3
   농축concentrated

실험 절차

A mixture of N1-(3-nitropyridin-2-yl)cyclohexane-1,4-diamine (500 mg, 2.11 mmol) and 2-chloro-1H-benzoimidazole (320 mg, 2.11 mmol) in N-methylpyrrolidinone (5 mL) was heated at 180° C. in microwave for 2 hours. The mixture was diluted with water (60 mL), and extracted with ethyl acetate (2×50 mL). The organic layer was dried over sodium sulfate and concentrated to give N1-(1H-benzo[d]imidazol-2-yl)-N4-(3-nitropyridin-2-yl)cyclohexane-1,4-diamine (400 mg, 1.13 mmol, 53.8% yield) which was used in the next step without further purification.

출처