반응 #794508

반응 방정식

cis-3-(((benzyloxy)carbonyl)amino)cyclobutyl 4-methylbenzenesulfonate

oxazolo[4,5-b]pyridin-2(3H)-one

potassium carbonate

→

benzyl (trans-3-(2-oxooxazolo[4,5-b]pyridin-3(2H)-yl)cyclobutyl)carbamate

용매

dimethylformamide

dichloromethane

반응 조건

후처리

1. 1
   세척washed with water and brine
2. 2
   건조then dried with magnesium sulfate
3. 3
   기타evaporated to dryness under reduced pressure

실험 절차

To a solution of cis-3-(((benzyloxy)carbonyl)amino)cyclobutyl 4-methylbenzenesulfonate (0.25 g, 0.666 mmol) in dry dimethylformamide (1.332 ml) was added oxazolo[4,5-b]pyridin-2(3H)-one (0.091 g, 0.666 mmol) and potassium carbonate (0.230 g, 1.665 mmol). The resulting mixture was heated at 50° C. for 14 hours, 100° C. for 3 hours, then 110° C. for an additional 20 hours. The mixture was diluted with dichloromethane and washed with water and brine then dried with magnesium sulfate and evaporated to dryness under reduced pressure. The crude was advanced directly to next step.

출처