반응 #7945

반응 방정식

9a-butyl-7-methoxy-8-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one

BBr3

→

solid

수율 99.1%

9a-butyl-7-hydroxy-8-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one

수율 99.1%

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   workup.ADDITIONwas added dropwise by syringe
2. 2
   기타The cooling bath was removed
3. 3
   workup.ADDITIONThe mixture was diluted with EtOAc (8 mL), water (3 mL) and 1N HCL (1 mL)
4. 4
   workup.STIRRINGshaken vigorously
5. 5
   기타The EtOAc layer was separated
6. 6
   세척washed with water (3 mL), 1M pH 3 phosphate (3 mL) and brine (3 mL)
7. 7
   건조dried over MgSO4
8. 8
   여과filtered
9. 9
   기타evaporated under vacuum

실험 절차

A solution of 9a-butyl-7-methoxy-8-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (28.4 mg, 0.1 mmol) in anhydrous CH2Cl2 (1.7 mL) was stirred under a nitrogen atmosphere and cooled in a dry ice-acetone bath while 1M BBr3 in CH2Cl2 (0.30 mL, 0.3 mmol) was added dropwise by syringe. The cooling bath was removed and the reaction mixture was stirred at room temperature for 4 hours. The mixture was diluted with EtOAc (8 mL), water (3 mL) and 1N HCL (1 mL) and shaken vigorously. The EtOAc layer was separated, washed with water (3 mL), 1M pH 3 phosphate (3 mL) and brine (3 mL), dried over MgSO4, filtered and evaporated under vacuum to give an ochre solid (26.8 mg). The crude product was suspended in CDCl3 (1 mL) and filtered. The solid portion was dried under vacuum to afford 9a-butyl-7-hydroxy-8-methyl-1,2,9,9a-3H-tetrahydro-fluoren-3-one as an olive colored powder.

출처