반응 #79389

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4-Chloro-6-bromoquinazoline

4-benzyloxyaniline

→

product

수율 88.1%

(4-Benzyloxyphenyl)-(6-bromoquinazolin-4-yl)-amine hydrochloride

수율 88.1%

용매

2-propanol

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후처리

1. 1
   온도heated
2. 2
   온도at reflux for 10 mins (Procedure A)
3. 3
   기타the 2-propanol removed in vacuo
4. 4
   기타The resulting solid was triturated with acetone

실험 절차

4-Chloro-6-bromoquinazoline (0.25 g, 1.0 mmol) and 4-benzyloxyaniline (0.25 g, 1.3 mmol) were mixed in 2-propanol (6 ml) and heated at reflux for 10 mins (Procedure A). The solution was allowed to cool at room temperature and the 2-propanol removed in vacuo. The resulting solid was triturated with acetone to give the product as a yellow solid (0.39 g, 88%); δH [2H6]-DMSO 11.60 (1H, b, NH), 9.21 (1H, s, 5-H), 8.86 (1H, s, 2-H), 8.20 (1H, d, 7-H), 7.90 (1H, d, 8-H), 7.65 (2H, d, 2′-H, 6′-H), 7.50-7.25 (5H, m, Ph-H), 7.10 (2H, d, 3′-H, 5′-H), 5.15 (2H, s, CH2); m/z 405/407 (M+).

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