반응 #792153

반응 방정식

2-chloro-3-trifluoromethylpyridine

3-trifluoromethylpyrazole

potassium carbonate

→

title compound

수율 62.2%

3-Trifluoromethyl-2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]pyridine

수율 62.2%

용매

반응 조건

후처리

1. 1
   기타The cooled reaction mixture
2. 2
   추출The mixture was extracted twice with ether (100 mL)
3. 3
   세척the combined ether extracts were washed twice with water (100 mL)
4. 4
   건조The organic layer was dried with magnesium sulfate
5. 5
   농축concentrated to an oil

실험 절차

A mixture of 2-chloro-3-trifluoromethylpyridine (3.62 g., 21 mmol), 3-trifluoromethylpyrazole (2.7 g., 20 mmol), and potassium carbonate (6.0 g, 43 mmol) were heated at 100° C. for 18 h. The cooled reaction mixture was added to ice/water (100 mL). The mixture was extracted twice with ether (100 mL) and the combined ether extracts were washed twice with water (100 mL). The organic layer was dried with magnesium sulfate and concentrated to an oil. Chromatography on silica gel with hexanes:ethyl acetate 8:1 to 4:1 as eluent gave the title compound (3.5 g) as an oil.

출처