반응 #792145

반응 방정식

(E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one

→

final compound

수율 84.7%

1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridine-2-yl)propan-1-one

수율 84.7%

용매

EtOAc

반응 조건

후처리

1. 1
   기타was conducted at atmospheric pressure room temperature until the starting material
2. 2
   여과The catalyst was filtered
3. 3
   기타the crude was purified by chromatography on silica gel (25% EtOAc/hexane)

실험 절차

In a 200 mL round-bottomed flask, (E)-1-(2-hydroxy-4-isobutoxyphenyl)-3-(pyridin-2-yl)prop-2-en-1-one (1.08 g, 3.63 mmol) and 80 mg of 10% Pd/C was mixed together in wet EtOAc (50 ml). Hydrogenation was conducted at atmospheric pressure room temperature until the starting material was gone. The catalyst was filtered and the crude was purified by chromatography on silica gel (25% EtOAc/hexane) to provide 0.92 g of final compound (82%) as off white solid.

출처