반응 #791579

반응 방정식

hydrochloric acid

3-(4-methoxyphenyl)propionic acid

lithium aluminum hydride

water

→

3-(4-methoxyphenyl)propanol

용매

ether

ether

반응 조건

후처리

1. 1
   workup.STIRRINGAfter stirring at room temperature for 30 minutes
2. 2
   온도the mixture was refluxed for 1 hours
3. 3
   온도After cooling
4. 4
   추출extracted with ether
5. 5
   세척The organic layer was washed with saturated aqueous solution of sodium chloride
6. 6
   농축concentrated under reduced pressure

실험 절차

A solution of the 3-(4-methoxyphenyl)propionic acid in 100 ml of anhydrous ether was added dropwise to a suspension of 1.10 g of lithium aluminum hydride in 50 ml of anhydrous ether with stirring at room temperature over 20 minutes. After stirring at room temperature for 30 minutes, the mixture was refluxed for 1 hours. After cooling, water was added with ice cooling, and the mixture was made acidic by further addition of 10% hydrochloric acid and then extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, driven over anhydrous magnesium sulfate and concentrated under reduced pressure to give 5.06 g of 3-(4-methoxyphenyl)propanol.

출처