반응 #79132

반응 방정식

water

triethylamine

6-(Chloroacetyl)-3,4-dihydroquinolin-2(1H)-one

4-(3-methoxyphenyl)-4-piperidinol

→

title compound

수율 46.0%

6-{[4-Hydroxy-4-(3-methoxyphenyl)-1-piperidinyl]acetyl}-3,4-dihydroquinolin-2(1H)-one

수율 46.0%

용매

DMF

반응 조건

후처리

1. 1
   기타at room temperature
2. 2
   여과The precipitate was collected by filtration
3. 3
   세척washed with dichloromethane (20 ml)
4. 4
   workup.STIRRINGThe solid was stirred in 0.5N NaOH (65 ml) for 1 hour at room temperature
5. 5
   여과the suspension was filtered

실험 절차

To a stirred solution of 6-(Chloroacetyl)-3,4-dihydroquinolin-2(1H)-one (7.30 g, 32.7 mmol) in DMF (32 ml) were added 4-(3-methoxyphenyl)-4-piperidinol (J. Labelled Compd. Radiopharm., 41, p464, 1998). (8.12 g, 39.2 mmol) and triethylamine (13.7 ml, 98.0 mmol) at room temperature under nitrogen. The reaction mixture was stirred for 4 hours at room temperature and poured into water (80 ml). The precipitate was collected by filtration and washed with dichloromethane (20 ml). The solid was stirred in 0.5N NaOH (65 ml) for 1 hour at room temperature and the suspension was filtered to afford the title compound (5.98 g, 46%) as a yellow solid.

출처