반응 #791262

반응 방정식

1-chloro-4-methylpyridazino[4,5-b]indolizine

piperazinecarboxaldehyde

→

title compound

4-(4-Methylpyridazino[4,5-b]indolizin-1-yl)-piperazinecarboxaldehyde

반응 조건

실험 절차

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of piperazinecarboxaldehyde at 150° C. gave the title compound as the free base, which was purified by flash chromatography (silica gel, 1 to 20% methanol:ethyl acetate) and converted to the dihydrochloride salt (MeOH/etheral HCl/diethyl ether), mp 325° C.

출처