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1-chloro-4-methylpyridazino[4,5-b]indolizine

4-(2-aminoethyl)morpholine

→

title compound

N-[2-(4-Morpholinyl)ethyl]-4-methylpyridazino[4,5-b]indolizin-1-amine

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실험 절차

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 27 equivalents of 4-(2-aminoethyl)morpholine gave the title compound as the free base which was converted to the dihydrochloride salt (MeOH/ethereal HCl/diethyl ether), mp 310° C. (dec).

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