반응 #79073

반응 방정식

7-amino-4-methylthiopyrido[4,3-d]pyrimidine

3-iodoaniline

→

7-amino-4-(3-iodoanilino)pyrido[4,3-d]pyrimidine

수율 61.8%

반응 조건

후처리

1. 1
   기타The resulting product is chromatographed over silica gel (5-7% MeOH/CH2Cl2)

실험 절차

A mixture of 7-amino-4-methylthiopyrido[4,3-d]pyrimidine (72 mg, 0.37 mmol) and 3-iodoaniline (1.25 g, 5.71 mmol) is stirred at 160° C. for 30 min. The resulting product is chromatographed over silica gel (5-7% MeOH/CH2Cl2) to give 7-amino-4-(3-iodoanilino)pyrido[4,3-d]pyrimidine (83 mg, 61%) as a light brown rosettes. 1H NMR (DMSO) δ 9.84 (1H, brs), 9.34 (1H, s), 8.44 (1H, s), 8.30 (1H, brs), 7.90 (1H, dd, J=7.9, 0.8 Hz), 7.47 (1H, d, J=7.7 Hz), 7.18 (1H, t, J=8.0 Hz), 6.66 (2H, brs), 6.46 (1H, s).

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