반응 #7906

ord-7df2cf2c036f4ca89fda9641812f2c45

반응 방정식

CCN(CC)CCCNc1nc(C2(c3ccc(Cl)cc3)CCC2)cs1
N′-{4-[1-(4-chlorophenyl)cyclobutyl]thiazol-2-yl}-N,N-diethylpropane-1,3-diamine
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
CCN(CC)CCCNc1nc(C2(c3ccc(Cl)cc3)CCC2)cs1.O=C(O)CC(O)(CC(=O)O)C(=O)O
N′-{4-[1-(4-chlorophenyl)cyclobutyl]thiazol-2-yl}-N,N-diethylpropane-1,3-diamine citrate salt

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타to give a colorless oil

실험 절차

A solution of N′-{4-[1-(4-chlorophenyl)cyclobutyl]thiazol-2-yl}-N,N-diethylpropane-1,3-diamine, 19, (78.9 mg, 0.209 mmol) and citric acid (40.2 mg, 0.209 mmol) in methanol (10 mL) was concentrated to give a colorless oil. The oil was dissolved in water (10 mL) and lyophilized to give N′-{4-[1-(4-chlorophenyl)cyclobutyl]thiazol-2-yl}-N,N-diethylpropane-1,3-diamine citrate salt, 20, as a white powder.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07087623B2uspto-grants-2006_08