반응 #79024

반응 방정식

4-bromo-2-fluorophenylacetonitrile

(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

→

4-(4,4-Dimethyl-2-oxo-1,4-dihydro-2H-benzo[d][1,3]oxazin-6-yl)-2-fluorophenylacetonitrile

용매

H2O

반응 조건

후처리

1. 1
   기타Prepared

실험 절차

Prepared according to procedure B from 4-bromo-2-fluorophenylacetonitrile (T. Alessi A. H. P. U.S. Pat. No. 4,895,862) and (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid. A grey solid; mp 253-256° C. 1H NMR (DMSO-d6) δ 10.35 (s, 1H) 7.67-7.49 (m, 5H), 6.97 (d, 1H, J=8.6 Hz) 4.09 (s, 2H) 1.67(s, 6H), MS [M−H]−m/z 309. Anal. Calc. For C18H15N2FO2.0.15 H2O: C, 69.07; H, 4.93; N, 8.95. Found C, 69.27; H 5.05; N, 8.50.

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