반응 #78973

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1-(4-amino-3′-chloro-biphenyl-3-yl)-1-cyclopropyl-ethanol

1,1′carbonyldiimidazole

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title compound

6-(3-Chloro-phenyl)-4-cyclopropyl-4-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one

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실험 절차

The title compound was prepared from 1-(4-amino-3′-chloro-biphenyl-3-yl)-1-cyclopropyl-ethanol and 1,1′carbonyldiimidazole according to Procedure C. Off-white solid: mp 158-159° C.; 1H-NMR (DMSO-d6) δ 10.3 (s, 1H), 7.74 (t, 1H, J=1.71 Hz), 7.67-7.57 (m, 3H), 7.47 (t, 1H, J=7.88 Hz), 7.39 (d, 1H, J=8.1 Hz), 6.95 (d, 1H, J=8.12 Hz), 1.7 (s, 3H), 1.45 (m, 1H), 0.48 (m, 2H), 0.28 (m, 2H); MS (APCI) m/z 314 ([M+H]+, 100%); Anal. Calc. For C18H16ClNO2: C, 68.9; H, 5.14; N, 4.46. Found: C, 68.13; H, 5.01; N, 4.36.

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