반응 #78931

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compound 2

Methanesulfonic acid 1-[1-(4-chloro-phenyl)-cyclobutanecarbonyl]-piperidin-3-ylmethyl ester

1-(2-hydroxyphenyl)piperazine

cesium carbonate

→

12

수율 32.0%

[1-(4-Chloro-phenyl)-cyclobutyl]-{3-[4-(2-hydroxy-phenyl)-piperazin-1-ylmethyl]-piperidin-1-yl}-methanone

수율 32.0%

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후처리

1. 1
   기타Compound 12 was prepared

실험 절차

Compound 12 was prepared using the method described in Example 3, starting with compound 2 (1.0 g, 2.60 mmol), 1-(2-hydroxyphenyl)piperazine (0.51 g, 2.86 mmol), and cesium carbonate (1.27 g, 3.90 mmol) to give 12 (0.39 g, 32%); C27H34ClN3O2, LRMS (m/z)=469 (MH+).

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