반응 #78852

반응 방정식

3-(3-pyridinyl)-2-propynol

→

title compound

수율 20.3%

3-(3-Pyridinyl)-2-propynal

수율 20.3%

용매

CH2Cl2

반응 조건

후처리

1. 1
   여과the reaction mixture was filtered through celite
2. 2
   세척washed with CH2Cl2 (2×50 mL)
3. 3
   농축concentrated in vacuo
4. 4
   기타Purification by flash chromatography

실험 절차

A solution of 3-(3-pyridinyl)-2-propynol (500 mg, 3.75 mmol) in CH2Cl2 (5 mL) was treated with activated manganous dioxide (3.3 g, 34.5 mmol) at 25° C. After 12 h, the reaction mixture was filtered through celite, washed with CH2Cl2 (2×50 mL), concentrated in vacuo. Purification by flash chromatography afforded the title compound (100 mg, 20%) as yellow brown oil. MS 133 (M+H)+.

출처