반응 #78849

반응 방정식

3,5-dibromopyridine

PPh3

2-pyridinyl zinc chloride

→

title compound

3-Bromo-5-(2-pyridinyl)-pyridine

용매

THF

THF

EtOAc

반응 조건

후처리

1. 1
   온도the resulting solution was warmed
2. 2
   온도to reflux for 16 h
3. 3
   세척washed with water (2×100 mL)
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   농축was concentrated in vacuo
7. 7
   기타Purification by flash chromatography (EtOAc)

실험 절차

A solution of 3,5-dibromopyridine (2.5 g, 10.5 mmol), PPh3 (210 mg, 0.8 mmol) in degassed THF (2 mL) was treated with Pd2(dba)3 (Tris(dibenzylideneacetone)dipalladium (0), 91.5 mg, 0.1 mmol) at 25° C. under N2. A solution of 2-pyridinyl zinc chloride (21 mL, 0.5 M in THF, Aldrich) in THF was added and the resulting solution was warmed to reflux for 16 h. The solution was allowed to cool to room temperature, diluted with EtOAc (200 mL), washed with water (2×100 mL), dried (MgSO4), filtered and was concentrated in vacuo. Purification by flash chromatography (EtOAc) afforded the title compound as a white solid. MS 236 (M+H)+.

출처