반응 #78816

반응 방정식

2,4-dichloro-8-methoxy-quinazoline

N,N-diisopropyl-ethylamine

aniline

→

2-chloro-8-methoxy-4-phenylamino-quinazoline

용매

isopropanol

반응 조건

후처리

1. 1
   온도to reflux for 45 min
2. 2
   기타The cold reaction mixture
3. 3
   여과is filtered
4. 4
   기타residue is crystallized from dichloromethane and hexanes

실험 절차

A solution of 2,4-dichloro-8-methoxy-quinazoline (prepared as described in J. Chem. Soc. 1948, 1759) (0.6 g), N,N-diisopropyl-ethylamine (0.87 ml), and aniline (0.26 ml) in isopropanol (10 ml) is heated to reflux for 45 min. The cold reaction mixture is filtered and residue is crystallized from dichloromethane and hexanes to give 2-chloro-8-methoxy-4-phenylamino-quinazoline, m.p. 245-246° C.

출처