반응 #78815

반응 방정식

HCl

2-chloro-8-methoxy-4-phenylamino-quinazoline

4-methoxy-aniline

→

8-methoxy-2-(4-methoxy-phenylamino)-4-phenylamino-quinazoline dihydrochloride

용매

isopropanol

dioxane

반응 조건

후처리

1. 1
   온도is heated for 3 min
2. 2
   기타to produce a melt which
3. 3
   기타Crystallization from isopropanol and diethylether

실험 절차

A mixture of 2-chloro-8-methoxy-4-phenylamino-quinazoline (1.20 g) and 4-methoxy-aniline (0.66 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (15 ml). 4N HCl in dioxane (0.2 ml) is added. Crystallization from isopropanol and diethylether yields 8-methoxy-2-(4-methoxy-phenylamino)-4-phenylamino-quinazoline dihydrochloride, m.p. 287-289° C., FAB-MS: (M+H)+=373. Analytical data: C22H20N4O2+HCl.

출처