반응 #78814

반응 방정식

2-chloro-4-phenylamino-quinazoline

N-(4-aminophenyl)-piperidine

HCl

→

2-[4-(piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride

용매

dioxane

isopropanol

반응 조건

후처리

1. 1
   온도is heated for 3 min
2. 2
   기타to produce a melt which
3. 3
   기타Recrystallization from ethanol and diethylether

실험 절차

A mixture of 2-chloro-4-phenylamino-quinazoline (0.18 g) and N-(4-aminophenyl)-piperidine (0.164 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (4 ml). 4 N HCl in dioxane (1 ml) is added. Recrystallization from ethanol and diethylether yields 2-[4-(piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride, Rf (A1) 0.64, FAB-MS: (M+H)+=396. m.p.: (decomposition).

출처