반응 #78777

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3-Bromoaniline

1,1,1-trifluoro-2,3-epoxypropane

→

3-[(3-bromophenyl)amino]-1,1,1-trifluoro-2-propanol

수율 84.0%

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후처리

1. 1
   기타The crude product was purified by flash column chromatography on silica gel eluting with CH2CH2:hexane (2:1)

실험 절차

EX-633A) 3-Bromoaniline (2.15 g, 12.5 mmol) and 1,1,1-trifluoro-2,3-epoxypropane (1.0 g, 8.9 mmol) were placed in a sealed vial, heated to 70° C. and stirred for 1 h under an atmosphere of nitrogen. The crude product was purified by flash column chromatography on silica gel eluting with CH2CH2:hexane (2:1) to give 2.11 g (84%) of the desired 3-[(3-bromophenyl)amino]-1,1,1-trifluoro-2-propanol product as a light amber oil, 98% pure by HPLC analysis. MS m/z=284/286 [M+H]+.

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