반응 #78760
ord-d62f8cb5cdc0409eab9dad90164d7a31
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The slurry was heated
- 2온도to reflux under argon for 2 h
- 3추출extracted with ethyl acetate
- 4세척The organic layer was washed with brine
- 5건조dried (MgSO4)
- 6기타evaporated to an oil
- 7기타Purification by flash chromatography on silica gel eluting with 5% ethyl acetate in hexane
실험 절차
EX-601A) To a toluene (10 mL) solution of 3-bromofuran (0.54 mL, 6.0 mmol) was added 3-formylphenylboronic acid (1.00 g, 6.7 mmol) and DMF (4 mL). To the resulting solution was added K2CO3 (1.85 g, 13.4 mmol) and Pd(PPh3)4 (0.40 g, 0.35 mmol). The slurry was heated to reflux under argon for 2 h. The cooled mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4) and evaporated to an oil. Purification by flash chromatography on silica gel eluting with 5% ethyl acetate in hexane gave 0.10 g (10%) of the desired 3-(3-furanyl)benzaldehyde product as a yellow oil. MS: m/z=173.0 [M+H]+.