반응 #78743

반응 방정식

3-Trifluoromethoxyaniline

3,3,3-trifluoro-1,2-epoxypropane

→

3-[(3-trifluoromethoxyphenyl)amino]-1,1,1-trifluoro-2-propanol

수율 88.5%

반응 조건

후처리

1. 1
   기타The excess aniline was removed by distillation (70° C. at 16.2 Torr)

실험 절차

EX-321A) 3-Trifluoromethoxyaniline (23.81 g, 134.4 mmol) and 3,3,3-trifluoro-1,2-epoxypropane (3.76 g, 33.6 mmol) were placed into a sealed tube and heated to 80° C. for 24 h. The excess aniline was removed by distillation (70° C. at 16.2 Torr) to give 8.6 g (88%) of the desired 3-[(3-trifluoromethoxyphenyl)amino]-1,1,1-trifluoro-2-propanol product as a light yellow oil. 1H NMR (CDCl3) δ 3.29-3.37 (m, 1H), 3.55 (dd, 1H), 4.20 (m, 1H), 6.48-6.63 (m, 3H), 7.12 (t, 1H). 19F NMR (CDCl3) δ −79.36 (s, 3F), −58.44 (s, 3F).

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