반응 #78631

ord-5ea9f7c83c2347fba7b0305cd5780c26

반응 방정식

CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
COC(=O)CCN(C(=O)c1cnc2c(c1)nc(CSc1ccc(C#N)cc1)n2C)c1ccccc1
3-methyl-2-[(4-cyanophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate
→
CCOC(=O)CCN(C(=O)c1cnc2c(c1)nc(CSc1ccc(C(=N)N)cc1)n2C)c1ccccc1.Cl
3-Methyl-2-[(4-amidinophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
수율 88.0%

반응물

—
C27H28N6O3S
CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
COC(=O)CCN(C(=O)c1cnc2c(c1)nc(CSc1ccc(C#N)cc1)n2C)c1ccccc1
3-methyl-2-[(4-cyanophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate

시약

없음

용매

CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Prepared analogously to Example 1 from 3-methyl-2-[(4-cyanophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 88% of theory, C27H28N6O3S (516.63); Rf value: 0.23 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=517; (M+H+Na)++=270.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06710055B2uspto-grants-2004_03