반응 #78512

ord-2aeab1c54ebd4574a37b654e7bdab530

반응 방정식

CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CSc1ccc(C#N)cc1)n2C)c1ccccc1
1-methyl-2-[(4-cyanophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate
→
CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CSc1ccc(C(=N)N)cc1)n2C)c1ccccc1.Cl
1-Methyl-2-[(4-amidinophenyl)thiomethyl]benzimidazol-5-yl-carboxlic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride
수율 90.0%

반응물

—
C28H29N5O3S
CCO.CCOC(C)=O.N
ethyl acetate ethanol ammonia
CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CSc1ccc(C#N)cc1)n2C)c1ccccc1
1-methyl-2-[(4-cyanophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide
Cl
hydrochloric acid
O=C([O-])[O-].[NH4+].[NH4+]
ammonium carbonate

시약

없음

용매

CCO
ethanol

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

Prepared analogously to Example 27 from 1-methyl-2-[(4-cyanophenyl)thiomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide, and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 90% of theory, C28H29N5O3S (515.64); Rf value: 0.24 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=516; (M+H+Na)++=269.7.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US06710055B2uspto-grants-2004_03