반응 #78507

반응 방정식

acetic acid

1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride

ethanol

sodium hydroxide

→

1-Methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-hydroxycarbonylethyl)amide

용매

water

water

반응 조건

후처리

1. 1
   기타The product which crystallized out
2. 2
   여과filtered
3. 3
   세척washed with water
4. 4
   기타dried at 60° C. in vacuo

실험 절차

A mixture of 300 mg (0.56 mmol) of 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride, 15 mL of ethanol, 4 mL of water and 120 mg (3.0 mmol) of sodium hydroxide was stirred for two hours at room temperature. Then the mixture was diluted with about 20 mL of water and made weakly alkaline with glacial acetic acid. The product which crystallized out was suction filtered, washed with water, and dried at 60° C. in vacuo. Yield: 250 mg (95% of theory), C26H26N6O3 (470.5); EKA mass spectrum: (M+H)+=471; (M+H+Na)++=247; (M+2Na)++=258.

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