반응 #7848

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2-[3-methoxy-4-(pyridin-3-ylmethyl)phenyl]-1,3-benzoxazole

2-[4-(bromomethyl)-3-methoxyphenyl]-1,3-benzoxazole

4-pyridylboronic acid

→

2-[3-methoxy-4-(pyridin-4-ylmethyl)phenyl]-1,3-benzoxazole

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후처리

1. 1
   기타reacted

실험 절차

Utilizing the general procedure outlined for 2-[3-methoxy-4-(pyridin-3-ylmethyl)phenyl]-1,3-benzoxazole, 2-[4-(bromomethyl)-3-methoxyphenyl]-1,3-benzoxazole (270 mg, 0.81 mmol), 4-pyridylboronic acid (100 mg, 0.81 mmol) reacted to afford the desired 2-[3-methoxy-4-(pyridin-4-ylmethyl)phenyl]-1,3-benzoxazole as a colorless solid: 1H NMR (CDCl3, 300 MHz) δ 8.46 (br s, 2H), 7.75–7.81 (m, 3H), 7.56–7.59 (m, 1H), 7.34–7.36 (m, 2H), 7.22 (d, 1H), 7.13 (d, 2H), 4.00 (s, 2H), 3.92 (s, 3H). MS (ESI) 317 (M+H)+.

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