반응 #78478

반응 방정식

4-cyanophenoxyacetic acid

2-amino-3-methylamino-6-methylpyridine

→

1,5-Dimethyl-2-[(4-cyanophenyl)oxymethyl]imidazo[4,5-b]pyridine

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.WAITAfter 2 hours at 60° C.
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   workup.ADDITIONthe crystalline residue was mixed with water
4. 4
   세척washed with water
5. 5
   기타dried
6. 6
   기타After crystallization from ethanol
7. 7
   기타9.95 g (91% of theory) were obtained in the form of white crystals

실험 절차

11.4 g (63 mmol) of 4-cyanophenoxyacetic acid were dissolved in 200 mL of absolute tetrahydrofuran and mixed at room temperature with 10.2 g (63 mmol) of N,N′-carbonyldiimidazole. After 15 minutes at 60° C., 5.70 g (41.5 mmol) of 2-amino-3-methylamino-6-methylpyridine were added. After 2 hours at 60° C., the solvent was distilled off and the crystalline residue was mixed with water, washed with water, and dried. After crystallization from ethanol, 9.95 g (91% of theory) were obtained in the form of white crystals. C16H14N4O (278.32). Mass spectrum: M+=278.

출처