반응 #78468

반응 방정식

methyl 6-methylamino-5-nitronicotinate

hydrogen

ethyl acetate ethanol ammonia

→

Methyl 5-amino-6-methylaminonicotinate

용매

ethanol dichloromethane

반응 조건

후처리

1. 1
   여과The catalyst was then filtered off
2. 2
   workup.DISTILLATIONthe solvent was distilled off in vacuo
3. 3
   기타The crude oily product obtained
4. 4
   기타was further reacted directly

실험 절차

To a solution of 3.1 g (15 mmol) of methyl 6-methylamino-5-nitronicotinate in 100 mL of ethanol/dichloromethane (3:1) was added 1 g of palladium on charcoal (10%) and the resulting suspension was hydrogenated at room temperature under 5 bar of hydrogen pressure for 1.5 hours. The catalyst was then filtered off and the solvent was distilled off in vacuo. The crude oily product obtained was further reacted directly. Yield: 2.4 g (92% of theory); Rf value: 0.44 (silica gel; ethyl acetate/ethanol/ammonia=90:10:1).

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