반응 #78415
ord-97c7f9063dd14d3996f8f3c303887406
반응 방정식
반응 조건
온도
80°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타the resulting reaction mixture
- 2온도The solution was cooled to room temperature
- 3추출extracted with ethyl acetate
- 4건조The organic extracts were dried over MgSO4
- 5농축concentrated
- 6기타The crude product was purified by column chromatography
- 7세척eluting with hexanes/ethyl acetate (2/1
실험 절차
trans-5-Methoxymethyl-3-tosyl-Cbz-pyrrolidine (3.55 g, 8.8 mmol) was dissolved in DMSO (8.8 mL). Finely ground NaCN(0.65 g, 13.2 mmol) was added, and the resulting reaction mixture was stirred 4 h at 80° C. The solution was cooled to room temperature, diluted with H20 (9 mL) and brine (9 mL), and extracted with ethyl acetate. The organic extracts were dried over MgSO4 and concentrated. The crude product was purified by column chromatography eluting with hexanes/ethyl acetate (2/1, v/v) to afford 2.09 g (87% yield) of the desired product as an oil.