반응 #78395

반응 방정식

2-n-butyl-4-chloro 1-[(2′-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1′biphenyl-4-yl) -methyl]-1H-imidazol-5-methanol methyl-isobutyl ketone

potassium hydroxide

charcoal

→

title compound

수율 94.3%

Losartan Potassium

수율 94.3%

용매

methanol

반응 조건

후처리

1. 1
   온도was refluxed for 3 h
2. 2
   여과filtered at room temperature
3. 3
   농축The filtrate was concentrated to a volume of 30 ml under diminished pressure
4. 4
   workup.ADDITIONafter addition of 160 ml of heptane again to a volume of 130 ml
5. 5
   여과the precipitated crystals were filtered
6. 6
   세척washed with cold heptane
7. 7
   기타dried at 70° C.

실험 절차

Under nitrogen, in a 500 ml flask a mixture of 200 ml of dry methanol, 20 g (0.026 mol) of 2-n-butyl-4-chloro 1-[(2′-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1′biphenyl-4-yl) -methyl]-1H-imidazol-5-methanol methyl-isobutyl ketone solvate and 1.45 g (0.026 mol) of potassium hydroxide was refluxed for 3 h, treated with 0.4 g of charcoal and filtered at room temperature. The filtrate was concentrated to a volume of 30 ml under diminished pressure, and after addition of 160 ml of heptane again to a volume of 130 ml. The suspension was stirred at 0° C. for 2 h, the precipitated crystals were filtered, washed with cold heptane and dried at 70° C. to give 11.3 g (92.5%) of the title compound.

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