반응 #78394

반응 방정식

2-n-butyl-4-chloro-1-[(2′-(2-triphenylmethyl -2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)-methyl]1H-imidazol-5-methanol methyl-isobutyl ketone

potassium hydroxide

charcoal

→

title compound

수율 88.4%

Losartan Potassium

수율 88.4%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 9 h
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated to a volume of 30 ml under diminished pressure
4. 4
   workup.ADDITIONafter addition of 150 ml of acetonitrile again to a volume
5. 5
   여과the precipitated crystals were filtered
6. 6
   세척washed twice with 25 ml of cold acetonitrile
7. 7
   기타dried at 70° C.

실험 절차

In a 500 ml flask a mixture of 200 ml of dry ethanol, 20 g (0.026 mol) of 2-n-butyl-4-chloro-1-[(2′-(2-triphenylmethyl -2H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)-methyl]1H-imidazol-5-methanol methyl-isobutyl ketone solvate and 1.45 g (0.026 mol) of potassium hydroxide was refluxed for 9 h, treated with 0.5 g of charcoal and filtered. The filtrate was concentrated to a volume of 30 ml under diminished pressure, and after addition of 150 ml of acetonitrile again to a volume: of 60 ml. The suspension was stirred at 0° C. for 1 h, the precipitated crystals were filtered, washed twice with 25 ml of cold acetonitrile and dried at 70° C. to give 10.6 g (88%) of the title compound.

출처