반응 #78352

반응 방정식

hydrogen chloride

compound

3-[3-(4-Amino-4-phenylpiperid-1-yl)propyl]-1-benzoyl-3-(3,4-dichlorophenyl)-piperidine

triethylamine

2-thenoyl chloride

→

expected product

수율 101.6%

1-Benzoyl-3-(3,4-dichlorophenyl)-3-[3-[4-(2-thenoylamino)-4-phenyl-piperid-1-yl]propyl]piperidine Hydrochloride Monohydrate

수율 101.6%

용매

DCM

DCM

반응 조건

후처리

1. 1
   기타This compound is prepared by the procedure
2. 2
   기타The residue is chromatographed on silica H
3. 3
   기타The product obtained
4. 4
   기타the precipitate obtained
5. 5
   여과is filtered off

실험 절차

This compound is prepared by the procedure described in step B of EXAMPLE 19, starting from 1.5 g of the compound obtained in step A of EXAMPLE 19, 0.55 g of triethylamine and 0.4 g of 2-thenoyl chloride in 10 ml of DCM. The residue is chromatographed on silica H using DCM and then a DCM/MeOH mixture (95/5; v/v) as the eluent. The product obtained is taken up with DCM and acidified to pH I by the addition of ethereal hydrogen chloride and the precipitate obtained is filtered off to give 0.99 g of the expected product, m.p.=198-200° C.

출처