반응 #78198

반응 방정식

3-[2-(t-butoxycarbonylamino)ethoxy]-4-iodobenzonitrile

methyl 2-acetamidoacrylate

tris(2-methylphenyl)phosphine

triethylamine

→

title compound

Methyl 2-acetamido-3-[2-(2-(t-butoxycarbonylamino)ethoxy)-4-cyanophenyl]acrylate

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타The solvent was evaporated
2. 2
   기타to obtain the crude product, which
3. 3
   기타was purified by the silica gel column chromatography

실험 절차

18.0 g (46.4 mmol) of 3-[2-(t-butoxycarbonylamino)ethoxy]-4-iodobenzonitrile was dissolved in 200 ml of dimethylformamide (DMF). 13.3 g (92.8 mmol) of methyl 2-acetamidoacrylate, 2.82 g (9.28 mmol) of tris(2-methylphenyl)phosphine, 1.04 g (4.64 mmol) of palladium (II) acetate and 12.9 ml (92.8 mmol) of triethylamine were added to the obtained solution, and they were stirred at 115° C. for 4 hours. The solvent was evaporated to obtain the crude product, which was purified by the silica gel column chromatography to obtain the title compound.

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