반응 #78179

반응 방정식

phthalic acid anhydride

4-methylpyrimidine

→

2-Pyrimidin-4-yl-indan-1,3-dione

용매

methanol

반응 조건

후처리

1. 1
   여과filtered
2. 2
   세척the residue washed with methanol
3. 3
   기타by evaporating the filtrate

실험 절차

7.87 g (53.1 mmol) phthalic acid anhydride and 22 ml (0.24 mol) 4-methylpyrimidine are stirred for 1 h at 140° C. and for 4 h at 21° C. The reaction mixture is then stirred with 15 ml methanol, filtered, and the residue washed with methanol. Further product is obtainable by evaporating the filtrate and stirring the residue with water: m.p.: 168-169° C.); Anal. calc.(C13H8N2O2) C, 69.64%; H, 3.60%; N, 12.49%. found C, 69.8%; H, 3.7%; N, 12.4%; FAB MS (M+H)+=225.

출처