반응 #7807
ord-597be74ec6884f958b11150971f674b4
반응 방정식
반응 조건
온도
90°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도The reaction was cooled to rt
- 2세척washed with H2O (2×50 mL)
- 3건조dried (MgSO4)
- 4여과filtered
- 5농축concentrated in vacuo
실험 절차
A mixture of 2-(3-{[tert-butyl-(dimethyl)silyl]oxy}-4-bromomethylphenyl)-1,3-benzoxazole (1.6 g, 3.8 mmol) and sodium cyanide (560 mg, 11.4 mmol) in DMF (10 mL) was stirred at 90° C. overnight. The reaction was cooled to rt and dissolved in EtOAc (200 mL), washed with H2O (2×50 mL), dried (MgSO4), filtered, and concentrated in vacuo to afford [4-(1,3-benzoxazol-2-yl)-2-hydroxyphenyl]acetonitrile as yellow solid. MS (ESI) 251 (M+H)+.