반응 #78014

반응 방정식

3-[3-(2-chlorophenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

aminoguanidine nitrate

HCl dioxane

HCl dioxane

sodium hydroxide

→

title compound

수율 86.9%

3-[3-(2-Chlorophenylsulfonyloxy)-5-methylphenoxy]propylaminoguanidine Diacetate

수율 86.9%

용매

ethanol

dichloromethane

water

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 15 min
2. 2
   추출extracted into dichloromethane (3×20 mL)
3. 3
   세척The organic phase was washed with water (3×20 mL)
4. 4
   건조dried (K2CO3)
5. 5
   농축concentrated
6. 6
   기타to give 321 mg of crude product as a free base
7. 7
   기타The solvent was removed
8. 8
   기타the product was triturated from a mixture of dichloromethane/ether/hexane

실험 절차

2-[2-[3-(2-Chlorophenylsulfonyloxy)-5-methylphenoxy]ethyl-1-methylene]hydrazinecarboximidamide hydrochloride: A solution of 289 mg (0.82 mmol) of 3-[3-(2-chlorophenylsulfonyloxy)-5-methylphenoxy]propionaldehyde, as prepared in the preceding step, 223 mg (1.62 mmol) of aminoguanidine nitrate, and 200 μL (0.80 mmol) of 4N HCl/dioxane in 3 mL of ethanol was stirred at ambient temperature overnight. The reaction mixture was treated with 10 mL of water and stirred for 15 min. The reaction mixture was treated with 1.2 mL of 2N sodium hydroxide and then extracted into dichloromethane (3×20 mL). The organic phase was washed with water (3×20 mL), dried (K2CO3), and concentrated to give 321 mg of crude product as a free base. The residue was dissolved in dichloromethane (1 mL), treated with 800 μL (3.2 mmol) of 4N HCl/dioxane solution. The solvent was removed and the product was triturated from a mixture of dichloromethane/ether/hexane to give 190 mg of the title compound as a colorless solid. 1H-NMR (300 MHz, DMSO-d6) δ 11.58 (br s, 1H), 7.95 (dd, 1H, J=7.9, 1.5 Hz), 7.90-7.80 (m, 2H), 7.52-7.61 (m, 6H), 6.77 (s, 1H), 6.49 (s, 1H), 6.46 (br t, 1H, J=2.2 Hz), 4.14 (t, 2H), 2.67 (q, 2H), and 2.21 (s, 3H). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C17H19ClN4O4S: 411.1 (M+H). Found: 411.1.

출처