반응 #78013

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5-Methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl)phenylsulfonyloxy]phenoxy]propoxyguanidine dihydrochloride

5-methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl) phenylsulfonyloxy]phenoxy]propoxyamine

α-cyano-4-hydroxycinnamic acid

→

title compound

수율 76.0%

3-[5-Methyl-3-(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl) phenylsulfonyloxy)phenoxy]propoxyguanidine Dihydrochloride

수율 76.0%

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후처리

1. 1
   기타as prepared in the preceding step, in a manner analogous to step f of Example 1

실험 절차

3-[5-Methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl)phenylsulfonyloxy]phenoxy]propoxyguanidine dihydrochloride: The title compound was prepared in 76% yield from 3-[5-methyl-3-[(2-(N-methyl-N-(3-pyridylmethyl)aminosulfonyl) phenylsulfonyloxy]phenoxy]propoxyamine, as prepared in the preceding step, in a manner analogous to step f of Example 1. 1H-NMR (300 MHz, DMSO-d6) δ 8.78 (t, J=5.2 Hz, 2H), 8.23 (m, 3H), 8.06 (t, J=7.7 Hz, 1H), 7.94 (t, J=7.7 Hz, 1H), 7.88 (t, J=7.9 Hz, 1H), 7.71 (br s, 4H), 6.75 (s, 1H), 6.55 (s, 1H), 6.51 (s, 1H), 4.72 (s, 2H), 3.99 (t, J=6.3 Hz, 2H), 3.90 (t, J=6.4 Hz, 2H), 2.88 (s, 3H), 2.22 (s, 3H), 2.01 (pentet, J=6.4 Hz, 2H). Mass spectrum (MALDI-TOF, α-cyano-4-hydroxycinnamic acid matrix) calcd. for C24H29N5O7S2: 564.2 (M+H), 586.1 (M+Na). Found: 564.1, 586.2.

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