반응 #77926

반응 방정식

4-chloro-5-methanesulfonyl-2-methylbenzoic acid

trimethyl orthoacetate

→

methyl 4,5-bis-methanesulfonyl-2-methylbenzoate

용매

NMP

반응 조건

후처리

1. 1
   기타had reacted completely
2. 2
   workup.DISTILLATIONAfter the excess orthoester had been distilled off
3. 3
   workup.ADDITION96.5 g of sodium methanesulfinate were added

실험 절차

A solution of 100.0 g of 4-chloro-5-methanesulfonyl-2-methylbenzoic acid and 68.1 g of trimethyl orthoacetate in 322 ml of NMP was refluxed until the acid had reacted completely. After the excess orthoester had been distilled off, 96.5 g of sodium methanesulfinate were added, and the mixture was stirred at 90° C. for 18 h. Conventional work-up gave methyl 4,5-bis-methanesulfonyl-2-methylbenzoate.

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