반응 #77857

반응 방정식

N-bromosuccimide

3,4-dihydro-2H-pyran

acetic acid

→

2-acetoxy-3-bromo-tetrahydropyran

수율 73.0%

용매

diethyl ether

반응 조건

후처리

1. 1
   세척washed with 50 ml of water three times
2. 2
   세척The organic layer was washed with 1N NaHCO3 solution
3. 3
   기타dried
4. 4
   농축concentrated under a reduced pressure

실험 절차

To the solution of N-bromosuccimide (4.5 g ) in acetic acid (14.5 ml), was added dropwise 2.3 ml of 3,4-dihydro-2H-pyran at 10° C. The reaction mixture was diluted with 50 ml of diethyl ether and washed with 50 ml of water three times. The organic layer was washed with 1N NaHCO3 solution, dried, and then concentrated under a reduced pressure to give 4.1 g of 2-acetoxy-3-bromo-tetrahydropyran as a colorless oil (yield: 73%).

출처