반응 #77853

반응 방정식

2,5-di(3-benzyloxycarbonylaminoprop-1-ynyl)pyridine

Benzyl 3-[5-(3-{[(benzyloxy)carbonyl]amino}prop-1-ynyl)pyridin-2-yl]prop-2-ynylcarbamate

hydrogen

→

12-1

수율 104.4%

3-[5-(3-aminopropyl)pyridin-2-yl]propyl amine

수율 104.4%

용매

methanol

반응 조건

후처리

1. 1
   여과The catalyst was filtered through Solka-flok
2. 2
   세척washed with methanol
3. 3
   세척The filtrate and wash
4. 4
   농축concentrated under reduced pressure

실험 절차

A solution of 2,5-di(3-benzyloxycarbonylaminoprop-1-ynyl)pyridine (8-1) (8.0 g) in methanol (160 mL) was hydrogenated under 20 psi of hydrogen gas pressure in the presence of 5%-Pd/Al2O3 (1.1 g) for 16 hours. The catalyst was filtered through Solka-flok and washed with methanol. The filtrate and wash were combined and concentrated under reduced pressure to give 12-1 (3.56 g) as a crystalline compound; m.p. 116-119° C.

출처