반응 #77845

반응 방정식

2,5-dibromopyridine

N-acetyl-propargylamine

water

→

2-1

N-(3-{5-[3-(acetamido)prop-1-ynyl]pyridin-2-yl}prop-2-ynyl)acetamide

용매

diisopropylamine

diisopropylamine

반응 조건

후처리

1. 1
   온도was refluxed for 3 hours under a nitrogen atmosphere
2. 2
   기타was removed from the mixture by distillation under reduced pressure
3. 3
   기타precipitates
4. 4
   여과were collected by filtration
5. 5
   기타dried under reduced pressure

실험 절차

A mixture of 2,5-dibromopyridine (15.0 g, 63.9 mmol), N-acetyl-propargylamine (15.51 g), and PdCl2(PPh3)2 (453 mg) in diisopropylamine (510 mL) was refluxed for 3 hours under a nitrogen atmosphere. To the mixture was added water (200 ml) and diisopropylamine was removed from the mixture by distillation under reduced pressure. The resulting suspension was aged at ambient temperature for 1 hour, and precipitates were collected by filtration and dried under reduced pressure to provide 2-1 (14.0 g).

출처