반응 #77835

반응 방정식

N-(cis)-{2-[(aminoacetyl)amino]cyclohexyl}-4-(aminosulfonyl)benzamide hydrogen bromide

3-chlorobenzenesulfonyl chloride

EtOAc

→

benzamide

수율 29.4%

4-(Aminosulfonyl)-N-{(cis)-2-[({[(3-chlorophenyl)sulfonyl]amino}acetyl)amino]cyclohexyl}benzamide

수율 29.4%

용매

DMF

반응 조건

후처리

1. 1
   세척the solution was washed with 1N HCl
2. 2
   건조The EtOAc was dried
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타Reverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue

실험 절차

N-(cis)-{2-[(aminoacetyl)amino]cyclohexyl}-4-(aminosulfonyl)benzamide hydrogen bromide, (61b), (70 mg) was dissolved in DMF (2.5 mL) prior to the addition of 3-chlorobenzenesulfonyl chloride (51 mg). After stirring overnight, EtOAc was added and the solution was washed with 1N HCl. The EtOAc was dried, filtered, and concentrated. Reverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue provided the title benzamide (25 mg). MS found: (M+H)+=530.1.

출처