반응 #77775

반응 방정식

5-Hydroxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

K2CO3

1,4-dibromobutane

→

5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester

용매

acetone

반응 조건

후처리

1. 1
   온도cooled to RT
2. 2
   여과filtered
3. 3
   농축concentrated

실험 절차

9.41 g (40 mmol) 5-Hydroxy-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester in 90 ml acetone were treated with 16.6 g (6 mmol) K2CO3 (powdered) and 17.3 g (5 mmol) 1,4-dibromobutane. The suspension was stirred at 50° C. for 4 h, cooled to RT, filtered and concentrated. Column chromatography on silica gel with CH2Cl2 yielded 8.8 g (60%) 5-(4-Bromo-butoxy)-2,3-dihydro-indole-1-carboxylic acid tert-butyl ester as colorless solid, MS: 370 (MH+, 1Br).

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