반응 #77701

반응 방정식

5-(2-aminophenyl)tetrazole

N,N-carbonyldiimidazole

imidazole

4-aminobiphenyl

→

4-Biphenylyl-2-(1-H-tetrazol-5-yl)phenyl urea

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   여과filtered
3. 3
   기타The filtrate was evaporated to dryness
4. 4
   기타the crude product purified by column chromatography
5. 5
   기타A yield of 0.28 g was obtained

실험 절차

To a solution of N,N-carbonyldiimidazole (0.96 g, 5.0 mmol) and imidazole (0.68 g, 10 mmol) in tetrahydrofuran (10 mL) at 0° C. was added 4-aminobiphenyl (1.0 g, 5.9 mmol) in tetrahydrofuran (10 mL). After stirring at 0° C. for 10 min 5-(2-aminophenyl)tetrazole (1.14 g, 7.1 mmol) was added. The reaction was stirred for another 4 hours and filtered. The filtrate was evaporated to dryness and the crude product purified by column chromatography. A yield of 0.28 g was obtained. M.p. 224-226° C.

출처