반응 #77660

반응 방정식

thiobenzamide

N-[2-(4-bromoacetyl-phenyl)-ethyl]-acetamide

→

material

수율 100.0%

N-{2-[4-(2-Phenyl-thiazol-4-yl)-phenyl]-ethyl}-acetamide

수율 100.0%

용매

ethanol

반응 조건

후처리

1. 1
   농축The reaction mixture was then concentrated in vacuo
2. 2
   기타to yield an off-white solid

실험 절차

In a round-bottomed flask, thiobenzamide (357 mg, 2.60 mmol) and N-[2-(4-bromoacetyl-phenyl)-ethyl]-acetamide (740 mg, 2.60 mmol) were combined in ethanol (30 ml) and heated to about 80° C. for about three hours. The reaction mixture was then concentrated in vacuo to yield an off-white solid. The resulting material (838 mg, 100% yield) was ascertained to be pure by NMR and was carried into the next step directly without further purification. LRMS ([M+H]+)=323.2.

출처