반응 #77604

반응 방정식

1-2-thienyl-1-propanone

ethylene glycol

trimethylsilyl chloride

→

2-Ethyl-2-2-thienyl-[1,3]dioxolane

반응 조건

후처리

1. 1
   추출After treatment with water, the medium is extracted with ethyl acetate
2. 2
   기타dried
3. 3
   농축concentrated under reduced pressure
4. 4
   기타The residue obtained
5. 5
   기타is purified by chromatography on a column of silica (eluent: 90 heptane/10 ethyl acetate)
6. 6
   기타A yellow oil is obtained (m=15 g; Y=38%)

실험 절차

30 g (214.3 mmol) of 1-2-thienyl-1-propanone are dissolved in 120 mL of ethylene glycol. 93 g (856 mmol) of trimethylsilyl chloride are then added. The reaction medium is stirred at room temperature for 24 hours. After treatment with water, the medium is extracted with ethyl acetate and the organic phases are then combined, dried and concentrated under reduced pressure. The residue obtained is purified by chromatography on a column of silica (eluent: 90 heptane/10 ethyl acetate). A yellow oil is obtained (m=15 g; Y=38%).

출처