반응 #77570

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1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine

4-trifluoromethylphenylboronic acid

→

title compound

수율 40.6%

1,4-Bis[5-(4-trifluoromethylphenyl)-2-pyridyl]hexahydro-1,4-diazepine

수율 40.6%

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후처리

1. 1
   기타The crude crystals were recrystallized from chloroform-hexane

실험 절차

Following the procedure of Example 1, crude crystals were obtained from the 1,4-bis(5-bromo-2-pyridyl)hexahydro-1,4-diazepine (206.0 mg, 0.500 mmol) synthesized in Reference Example 1 and 4-trifluoromethylphenylboronic acid (227.0 mg, 1.20 mmol). The crude crystals were recrystallized from chloroform-hexane to yield the title compound as colorless needles (melting point: 236.0-238.0° C.) (110.0 mg, yield: 40%).

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