반응 #7741

반응 방정식

Oxone

2-methyl-sulfanyl-pyrimidine-4-carboxylic acid methyl ester

methanol THF

→

desired product

2-methanesulfonyl-pyrimidine-4-carboxylic acid methyl ester

반응 조건

후처리

1. 1
   기타The resulting suspension is partitioned between methylene chloride and water
2. 2
   workup.ADDITIONwith the addition of NaOH and re
3. 3
   추출extracted with solvent
4. 4
   기타The combined organic layers are dried
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

An aqueous solution (1 L) of Oxone® (211.7 g, 344 mmol) is added dropwise at 0° C. to a solution of 2-methyl-sulfanyl-pyrimidine-4-carboxylic acid methyl ester, 14, (19 9,86.1 mmol) in 1:1 methanol/THF (1 L). The reaction solution is allowed to warm to room temperature and stir for 1.5 hours. The resulting suspension is partitioned between methylene chloride and water. The aqueous phase is made alkaline with the addition of NaOH and re extracted with solvent. The combined organic layers are dried, filtered, and concentrated in vacuo to afford 18.4 g of the desired product as a yellow oil.

출처