반응 #7737

반응 방정식

HCl

4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester

thionyl chloride

→

desired product

수율 97.0%

4-methylene-pyrazolidine-1-carboxylic acid 1-benzyl ester

수율 97.0%

용매

methanol

반응 조건

후처리

1. 1
   기타Concentration of the reaction in vacuo
2. 2
   기타affords a yellow oil which
3. 3
   기타crystallizes

실험 절차

To a solution of crude 4-methylenepyrazolidine-1,2-dicarboxylic acid 1-benzyl ester 2-tert-butyl ester, 8, (30 g) in methanol (300 mL) is added thionyl chloride dropwise at 0° C. The reaction is warmed to room temperature and stirred an additional 18 hours. Concentration of the reaction in vacuo affords a yellow oil which crystallizes upon standing to provide 23 g (97% yield) of the desired product as the HCl salt.

출처